Майкл Стюарт Браун

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Майкл Стюарт Браун
ағылш. Michael Stuart Brown
Mike Brown 2003.jpg
Майкл Браун (2003).
Туған күні

13 сәуір 1941 (1941-04-13) (80 жас)

Туған жері

Бруклин, Нью-Йорк, АҚШ



Ғылыми аясы

генетика, биохимия

Жұмыс орны

Даллас Техас университеті


Пенсильвания университеті

Несімен белгілі

исследователь регуляции метаболизма холестерина


Луиза Гросс Хорвиц жүлдесі (1984)
Nobel prize medal.svg Физиология немесе медицина саласындағы Нобель сыйлығы (1985),
АҚШ Ұлттық ғылыми медалі (1988)
Олбани медицина орталығының жүлдесі (2003)

Майкл Стюарт Браун (ағылш. Michael Stuart Brown; 13 сәуір, 1941, Бруклин, Нью-Йорк, АҚШ) — танымал америкалық дәрігер және биохимик. Тұқымқуалаушылық гиперхолестеринемииді зерттегені төмен тығыздықты липопротеинді рецепторды Джозеф Голдштейнмен бірге ашқаны үшін 1985 жылғы Физиология немесе медицина саласындағы Нобель сыйлығы.

Өмірбаян[өңдеу | қайнарын өңдеу]

Майкл Браун Пенсильвания университетін 1962 жылы бітіріген соң 1966 жылы, университеттің медициналық мектебін бітірді. Содан бері, Холестерин метаболизмі саласында Оңтүстік-Батыс медициналық орталығы жұмыс істейді (Техас университеті). Жетекші биологиялық және медициналық журналдарда көптеген мақалалардың авторы. 1985 жылы ол өзінің тығыздығы төмен липопротеинді рецепторды ашқаны үшін Нобель сыйлығын алды.

Библиография[өңдеу | қайнарын өңдеу]

Негізгі ғылыми жарияланымдары:

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[16] Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages. Science. 1983 Feb 18;219(4586):871-3.

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[25] Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science. 1985 Jan 11;227(4683):140-6.

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[28] Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell. 1985 мамыр;41(1):249-58.

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[38] Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science. 1988 Mar 11;239(4845):1277-81.

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[40] Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors. Science. 1990 Nov 30;250(4985):1273-5

[41] Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 1991 мамыр 3;65(3):429-34.

[42] cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1. Cell. 1991 Jul 26;66(2):327-34.

[43] Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product. Cell. 1992 Sep 18;70(6):1049-57.

[44] Koch’s postulates for cholesterol. Cell. 1992 Oct 16;71(2):187-8.

[45] cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. Cell. 1993 Jun 18;73(6):1091-9

[46] SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell. 1993 Oct 8;75(1):187-97.

[47] Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell. 1994 Mar 11;76(5):865-73.

[48] SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 1994 Apr 8;77(1):53-62

[49] Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell. 1996 Jun 28;85(7):1037-46

[50] Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell. 1996 Nov 1;87(3):415-26.

[51] The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997 мамыр 2;89(3):331-40.

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[53] Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell. 2000 Feb 18;100(4):391-8.

[54] Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell. 2000 Aug 4;102(3):315-23.

[55] Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell. 2002 Aug 23;110(4):489-500.

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